Auto-DMs.  They're driving people on Twitter over the edge.  I've had so many people ask me why would any rational human being, when after first meeting someone on Twitter, spam them with auto-responses when they would never act that way in person.  And although I've tackled that question  in my Unleashed blog (Spamming the Twitterverse), I'll offer a brief summary here because it's important to the gist of that blog. 

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